La pagina del proyecto en OPENNTF dice que no habria problema en usarlo bajo esas condiciones
"The server task uses "contig.exe" (v1.55) to defrag Domino databases on all 32bit and 64bit Windows server versions and will also defrag a full-text index associated with a Notes database and the Domino server’s transaction log and DAOS files. When DominoDefrag_EnterpriseSupport=1 (on), the output is recorded to CSV files and sent to the DominoDefrag Administrator for processing attached to a summary email.
DominoDefrag has the added functionality of being able to compact a database prior to defragging and supports multi-processing (can load multiple times to run concurrently) and use of an indirect file (.ind) to have the same compact batch functionality."
Un saludo